Need fast 1. which of these was not one of the "five nations" most affected by the indian removal act? creek cherokee chickasaw comanche 2. per the indian removal act, native americans were to be relocated west of the great lakes great plains mississippi river appalachian mountains 3. what was andrew jackson's reaction to the supreme court decision in worcester v. georgia? he ignored it. he appealed it. he tried to enforce it. he ordered the army to enforce it.