the affected woman in generation IV is thinking about her future and ask her oncologist whether she can know wheter any or all her children will have a high risk of the same cancer. The doctor would be expected to advise which of the followingg (I) genetic counseling; (II) prenatal diagnosis when/if she becomes pregnant; (III) testing to see whether she has the allelle; (IV) testing to see whether her future spouse or partner has the allelle

(I), (II) and (IV)  

Explanation:

In genomic medicine, genetic counseling refers to the process of advising patients of the risks and predisposition to suffer genetically inherited disorders/conditions (in this case, cancer predisposition), as well as for seeking consent for genetic testing when appropriate. This information is very useful for patients since it may help them to consider options regarding risk management and family planning. Moreover, prenatal diagnosis, also known as prenatal screening, is the procedure that aims at identifying genetically inherited health problems before birth.  Chorionic villus sampling and amniocentesis are two major prenatal testing methods used to identify possible fetal genetic abnormalities. Finally, genetic "carrier testing" is the procedure to identify the presence of undesirable gene variants (i.e., alleles) in an individual (in this case, the partner or spouse) related to the risks of transmitting genetic diseases and/or disabilities to their children.