Explain the difference between a dominant negative mutation and haploinsufficiency at the molecular level. an enzyme, encoded by gene a, converts substrate x into product y. individuals with a rare dominant mutation in gene a have severe neurological symptoms. if you could purify protein a from affected and unaffected individuals, how would you determine if the symptoms were caused by a dominant negative mutation versus haploinsufficiency. in your answer, explain your experimental results.

You are assigned to care for david ramsey, a 22-year old male patient with back injury secondary to being thrown from a motorcycle. did nt damage the spinal, but the computed tomography revealed a compression fracture at l-2. david complains of severe back pain with numbness and tingling in the lower extremities. what assessments are indicated based on this nursing diagnosis? list other major nursing diagnoses based on david’s clinical presentation?

In regards to acetyl coa in the tca/kreb's cycle: how many cycles minimum would it take for an acetyl coa carbon to be removed? (what is the first step that this removal could happen? why can't we know for sure how many turns it takes?

Acharge nurse is observing a newly licensed nurse provide care to a group of clients. which of the following actions by the newly licensed nurse requires an incident report by the charge nurse? a. a client who has a lithium level of 1.8 meq/l receives her morning dose of lithium. b. the nurse administers ondansetron to a client who has two episodes of vomiting after receiving meperidine 75 mg im. c. the nurse requests a higher dose of morphine for a client who reports severe pain 30 min after receiving morphine 2 mg iv bolus. d. a client who has a blood glucose level of 120 mg/dl receives her morning dose of insulin.