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Biology, 02.07.2021 15:50 hayesvolcano
It was found that the C4 protein promotes synaptic pruning during brain development in the teenage years. This is a normal process in brain development that is important for removing unnecessary connections between neurons and establishing a mature brain structure. However, high expression levels of a certain allele of C4 can lead to too much pruning, which may promote the onset of schizophrenia. The variation observed at the C4 gene which leads to the greatest increase in risk was found to cause a 25% increase in the risk of developing schizophrenia. The baseline risk in the population is 1%. What is the risk of an individual with this variant developing the condition
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