Suppose you have binding of a certain Kd. If you wanted to change the molecule so it bound more tightly you might have an effect either on the "on rate constant " or the "off rate constant" or both. To increase affinity how these rate constants need to change? Drugs normally act by binding to some receptor or enzyme. Suppose a drug is given so that its concentration in cells is around the Kd for the ligand that it binds to. How much more effect could you expect if you gave 10X as much drug. What else might you expect to happen

What does serving the court mean in civics

Tracey is a financial planner who received his cfp designation. tracey does not have any other designations or licenses. although tracey's expertise is investment planning, he is anxious to expand his client base and is willing to assist clients with any area of financial planning. over the last month tracey engaged in the following activities with troy, a new client. a. during the initial meeting, tracey collected personal data about troy including the estate planning documents troy had previously executed. b. during the second meeting, tracey recommended the use of a trust to fulfill some of troy's estate planning goals. c. troy called tracey one afternoon and asked if tracey could explain the probate process to him, which tracey promptly did. d. tracey downloaded a copy of a generic will from the internet, filled in troy's information and gave the document to troy to be executed. of the activities above, which would be considered the unauthorized practice of law?

Sariah enters a room with several chirping crickets in it. upon first entering the room, sariah can hear the chirping; however, as she begins to talk to her friends, she is no longer aware of the chirping even though it is still there. the fact that sariah no longer perceives the chirping sound demonstrates sensory