What were some challenges that the settlers faced as they were moving out west, during manifest destiny?

One challenge that settlers were facing when moving west during Manifest destiny were the native americans that were already living there, that clearly did not want to give up their land.

Ithink the answers is c i hope it my friend message me if i’m wrong and i’ll change my answer and fix it for you

3. i would say one, but one is not prime nor composite.