How did the First Punic War differ from the Second Punic War? Rome started the first war because she felt that Carthage's ownership of Sicily was too big of a threat. They started the second war out of pure greed.
Rome reaped a bounty of roads, resources and slaves after the first war, but lost the second war because of a failed campaign by Hannibal.
Carthaginians started the first war and Rome started the second war.
Carthage had to pay a massive tribute when losing the first war, but she was utterly destroyed in the second war.

The three Punic Wars between Carthage and Rome took place over nearly a century, beginning in 264 B.C. and ending in Roman victory with the destruction of Carthage in 146 B.C. By the time the First Punic War broke out, Rome had become the dominant power throughout the Italian peninsula, while Carthage–a powerful city-state in northern Africa–had established itself as the leading maritime power in the world. The First Punic War began in 264 B.C. when Rome interfered in a dispute on the Carthaginian-controlled island of Sicily; the war ended with Rome in control of both Sicily and Corsica and marked the empire’s emergence as a naval as well as a land power. In the Second Punic War, the great Carthaginian general Hannibal invaded Italy and scored great victories at Lake Trasimene and Cannae before his eventual defeat at the hands of Rome’s Scipio Africanus in 202 B.C., which left Rome in control of the western Mediterranean and much of Spain. In the Third Punic War, the Romans, led by Scipio the Younger, captured and destroyed the city of Carthage in 146 B.C., turning Africa into yet another province of the mighty Roman Empire.

Background and First Punic War (264-241 B.C.)

Tradition holds that Phoenician settlers from the Mediterranean port of Tyre (in what is now Lebanon) founded the city-state of Carthage on the northern coast of Africa, just north of modern-day Tunis, around 814 B.C. (The word “Punic,” later the name for the series of wars between Carthage and Rome, was derived from the Latin word for Phoenician.) By 265 B.C., Carthage was the wealthiest and most advanced city in the region, as well as its leading naval power. Though Carthage had clashed violently with several other powers in the region, notably Greece, its relations with Rome were historically friendly, and the cities had signed several treaties defining trading rights over the years.