What was a major difference between the Israelites and the Canaanites?

The major difference was that the Israelite were monotheism  ( worship only one God) WHILE the Canaanites where polytheism ( worship of two or more god)

Explanation:

The Israelite's who where  the descendant of the ancient Hebrew serve  only one God as a monotheist are known to be the member of the 12 tribes in Israel WHILE the Canaanites are polytheist who serve different gods in the form of idols  and they live in the land of Canaan.

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