A male manager stands, smiling, as a worker from another unit makes a remark to his female subordinate about her appearance that she considers to be sexually demeaning. This male manager has exhibited .

hostile work environment

Explanation:

hostile work environment refer in which one employee feel uncomfortable or irritated due to other employee behavior and one of most common act is  sexually harassment, gazing, touching,  dirty jokes, negative comments which make other employee uncomfortable. so in this example male manager exhibit hostile work environment.

the secretary of state, appointed by the president with the advice and consent of the senate, is the president's chief foreign affairs adviser. the secretary carries out the president's foreign policies through the state department and the foreign service of the united states.

explanation:

allergens: overstimulate the nerve system

neurotics: attack nerve cells

mutagens: damage or otherwise alter dna sequence

generators: cause defects during growth and development  

carcinogens: cause unchecked cell growth

i hope you get the idea according to me these are the effects that happened.