Quizket harlequin ichthyosis a rare genetic disorder causes the skin to become thick and scaly?

Correct.

Explanation:

Harlequin ichthyosis is an extremely rare skin disease of the group called genodermatosis (group of hereditary dermatoses with metabolic disorders), it is also usually classified in autosomal recessive congenital ichthyosis (ARCI, for its acronym in English) next to ichthyosis lamellar and non-bullous congenital ichthyosiform erythroderma. It is the most serious form of congenital ichthyosis, it has become evident since birth and owes its name to the appearance of newborns suffering from the disease, reminiscent of a harlequin costume. Harlequin-type ichthyosis is a rare genetic disease of the skin characterized by large, thick scales that appear throughout the skin, as in turn is born with the eyelids turned so that instead of eyes the eyelids are completely red. It is usually associated with characteristic facial deformities and often abnormalities in other parts of the body, especially in the chest.

It is due to an alteration of keratinization whose pathophysiological mechanism is unknown, but it is believed that there is a dysgenesis of the lamellar layer, probably due to abnormalities of the skin's lipids, which results in massive follicular hyperkeratosis.