Which best describes the languages spoken by american indians in south carolina? all tribes in south carolina spoke the same langauge most american indians spoke algonoquian or siouan. american indians spoke more than fifty languages most tribes spoke of four main langauges how were many american indians tribes in south carolina alike? they settled in the eastern part of the state they build villigaes that were cloes in size they use smilar farming methods they practiced the same religion.