The inability to flex the knee past 60 degrees has a pretest probability of 6% for a fracture of the knee (McGee, 2018 pg 694). This same physical exam finding has a positive likelihood ratio of 4.7 (pg 505). Approximate the post-test probability for a fracture of the knee, based on this one finding, (Hint: You are going to APPROXIMATE (not calculate) based on the instructions given on page 13 of McGee.

Mr. wayne is a 38-year-old man with a significant history of elevated cholesterol levels. his father died at age 42 from a massive heart attack secondary to elevated cholesterol and triglycerides, and two of his older siblings are currently taking medications to lower their cholesterol levels. mr. wayne makes an appointment to discuss his risk for hypercholesterolemia. the nurse recognizes that mr. wayne is at risk for familial hypercholesterolemia because this is an autoomal dominant inherited condition. a. describe the pattern of autosomal dominant inheritance. b. mr. wayne asks what chance his children have of developing familial hypercholesterolemia. how should the nurse respond? c. explain the phenomenon of penetrance observed in autosomal dominant inheritance.