• Um menino de 7 anos, 30kg, receberá fenobarbital para tratamento de epilepsia. Calcule a dose de manutenção que produzirá concentração plasmática de 25mg/L. Sabe-se que o Cl de fenobarbital é maior em crianças = 2mL/kg/h. Dose de manutenção = CSS . CL. T 25mg/L x 2mL/Kg/h 50mg/Kg/h
F. S 0,9 x 0,95 0,855
Dose de manutenção = 58,47 mg/kg/h

Sabendo que o menino usará comprimidos que somam a dose de 120mg/dia, analise o impacto desta dose para a concentração plasmática.
2mL/Kg/h x 24h = 48mL/Kg/dia
CSS = F.(D/T) CSS = 0,9 (120mg/dia CSS = 2,25 mg/mL
Cl 48mL/Kg/dia

• Qual seria a faixa de dose que este paciente poderia receber sabendo que a faixa terapêutica do fenobarbital é 15-40mg/L?

Congenital diseases are which of the following? genetic fatal disfiguring noninfectous

A10-year-old girl suffered from a rare malignancy in her brain and around her spinal cord. she had surgery, and most of the tumor mass was removed, but residual tumor remained in the brain and around the spinal cord. the girl's doctors informed her parents that chemotherapy and radiation were possible treatment options but could cause serious problems such as sepsis, a permanent loss of iq and stature, and even death. the parents wished to proceed with the therapy. while their child was undergoing aggressive chemotherapy and radiation, the parents did independent research and read of several drugs being administered for cancer in other states that were unapproved by the federal drug administration (fda) and were illegal in their home state but were touted by physicians using them as miracle cures." furthermore, one of the girl's doctors released the girl's medical records to another physician to get a "second opinion" without informing the parents. this particular physician is a member of the same country club as the parents. he happens to share facts from the medical records with other members who end up telling the girl's parents. the couple sued their child's physician for failure to disclose alternative treatments, thus depriving them of informed consent. the couples also sued the child's physician for sharing their daughter's records in violation of the girl's privacy. how should the court rule in both cases? did the child's physician involved follow the law? did he act ethically in either situation? explain your answer. under the doctrine of informed consent, should a physician be responsible for informing patients of all treatment options, even if some of the treatments are illegal or not yet proven effective?

Anurse is teaching about a new prescription for infliximab to a client who has rheumatoid arthritis. which of the following information should the nurse include in the teaching? a. “you will receive a mantoux test before the initial medication dose.” b. “you might experience diarrhea during the first 2 weeks of treatment.” c. “you will receive the medication every week for 6 weeks.” d. “you should receive the intranasal influenza vaccine.”