Ahypertensive patient was prescribed the diuretic lasix (furosemide) to increase urinary output. furosemide, a "high-ceiling" diuretic, is a potent agent because it binds to and inhibits which of the following transport processes?
a. the na+-glucose cotransporter in the proximal tubule
b. the na+-k+ exchange pump in all nephron segments
c. the na+-k+-c-cotransporter in the thick ascending limb
d. the na+-cl- cotransporter in the distal convoluted tubule
e. the na+ channel in the cortical collecting duct

Mrs. h, age 42 years, is experiencing severe rheumatoid arthritis in her wrists, fingers, and knees. the joints are quite inflamed, red, and swollen. she is sitting rigidly in a chair and refuses to put on a sweater, even though she is shivering, or let anyone touch her arms. she has been prescribed an analgesic and an anti-inflammatory drug, but her dose is not due for another hour. she is feeling nauseated, so she has not eaten for the past 8 hours. based on patient history and the signs and symptoms, discuss how the effects of pain are exacerbating her condition.