Which of the following is true with respect to the effectiveness of ssris and tricyclic antidepressants in treating depression? multiple choice ssris and tricyclic antidepressants have less effect when given in high doses. while tricyclic antidepressants are effective, they cannot be given in combination with ssris. incorrect ssris and tricyclics show comparable effectiveness in the treatment of depression. mao inhibitors are more effective than a combination of ssris and tricyclic antidepressants.