Expand fully (x+1)(x+2)(x+3)

The vertex of this parabola is at (-2,-3). when the x-value is -1, the y-value is -5. what is the coefficient of the squared expression in the parabola's equation?

During a wright loss challenge your friend goes from 125 pounds to 100 pounds. what was the percent weight loss

Me because i don't understand how to do it.: )