Amikacin 80 mg is ordered IVPB q 12 h. The amikacin is dissolved in 100 mL D5W and is to be infused over 30 minutes. With a tubing drop factor of 15 gtt/mL, how many drops per minute should be given (Fluharty, 022019) Fluharty, L., Ogden, S. (022019). Calculation of Drug Dosages, 11th Edition. [[VitalSource Bookshelf version]]. Retrieved from vbk://9780323551281

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Consider the linear model for a two-stage nested design with b nested in a as given below. yijk=\small \mu + \small \taui + \small \betaj(i) + \small \varepsilon(ij)k , for i=1,; j= ; k=1, assumption: \small \varepsilon(ij)k ~ iid n (0, \small \sigma2) ; \small \taui ~ iid n(0, \small \sigmat2 ); \tiny \sum_{j=1}^{b} \small \betaj(i) =0; \small \varepsilon(ij)k and \small \taui are independent. using only the given information, derive the least square estimator of \small \betaj(i) using the appropriate constraints (sum to zero constraints) and derive e(msb(a) ).