How do u solve this?

-410

Step-by-step explanation:

Replace the letters with the numbers:

-5(2-5×-4^2)

Solve the -4^2 (then you get -16)

-5(2-5×-16)

Multiply -5 and -16 (to get 80)

-5(2+80)

Add 2 to 80 (to get 82)

-5×82

Multiply

-410