A triangle on a coordinate plane is translated according to the rule T3.5(x, y). Which is another way to write this rule?
(x, y) - (x - 3, y + 5)
(x, y) → (x-3, -5)
(x, y) - (x + 3, y-5)
(x, y) → (X + 3, y + 5)

Which of the following is the major negative aspect of crossover designs for research studies? a. prohibitive cost b. residual effects c-subject drepout d. incomplete randomization e. large sample size required