In rats not exposed to an electromagnetic field (sample size in parentheses), is there significant evidence of a difference in the tumor rates between males and females? Are the conditions for the z ‑test for comparing two proportions met?

No, because the two population might have different distributions.
No, because the samples are not random and are not large enough.
Yes, because all expected counts are larger than five.
Yes, because the samples are random and the smallest count is 16.