The first permanent 1 colony in the new world was at:
massachusetts bay colony
plymouth colony
jamestown
new netherland
new sweden

Jamestown,founded in 1607,was the first successful permanent English settlement in what would become the United States.It was located on Jamestown Island,  in Virginia

The constant presence of diseases or infectious agents within a given geographic area or population group. it may also refer to the usual prevalence of a given disease with such area or group. it includes holoendemic and hyperendemic diseases. a holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). a hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. so probably family history.