How did santo domingo influence american expansion?

The first foundation in the Antilles was the city of Santo Domingo, which was the nucleus of the primitive Spanish occupation of America. The colonization in Santo Domingo was the first test of Spanish conquest and colonization in America. There arose the starting points of the colonial administration that later expanded throughout the continent. They practiced an economy of planters, the search for gold and the exploitation of deposits led to a rapid demographic decline in Santo Domingo.

Do you have more info about it ? i doubt this is the answer because i don't have all the information but if trouble was brewing in a clinic maybe it was an argument as to which clinic was better or smth of that nature