Which best describes the vatican’s relationship with spain during the 15th century? spain and the vatican were sworn enemies after spain invaded and sacked naples. spain and the vatican combined forces to overtake the house of habsburgs. spain and the vatican formed the schmalkaldic league to fight the french. spain was fervently catholic and spanish gold raised numerous buildings in rome.

The correct answer should be Spain was fervently Catholic and Spanish gold raised numerous buildings in Rome.

Ferdinand the Catholic was the King then and he worked together with pope in waging wars around Italy. He also established the Spanish Inquisition in order to make sure that Catholic orthodoxy became the only allowed religion in Spain since he managed to kick out Muslims out of the country.