One major way that the lewis and clark expedition affected american business was that the explorers found a location for a national bank. located important routes for trade and travel. brought back specimens of natural discoveries. found a water route across the continent.

One major way that the Lewis and Clark expedition affected American business was that the explorers located important routes for trade and travel.

Explanation:

The Lewis and Clark Expedition was the first carried out by Americans who crossed the west of the current United States. The expedition members left from near San Luis (Missouri), went west and crossed much of North America to reach the Pacific Ocean coast.

The expedition was commissioned by President Thomas Jefferson immediately after the Louisiana Purchase in 1803. It was composed of a select group of volunteer officers of the United States Army under the command of Captain Meriwether Lewis and his friend, Second Lieutenant William Clark. Their dangerous journey lasted from May 1804 to September 1806. The main objective was to explore and map the newly acquired territory, open a safe route through the western half of the continent and establish American presence in the extensive area before Great Britain or other European claimed it.