Which was the greatest challenge for both american settlers and american indians in the west in the mid-1800s?
a. the exposure to harsh weather
b. the threat of deadly diseases
c. the danger of crossing difficult terrain
d. the problem of fenced-off land

b. the threat of deadly diseases

Explanation:

The greatest challenge for the american settlers and the native americans in the midwest were the threat of deadly diseases, the mid west was formed by little towns and cities that were close to the roads that connected the East with the West and thrived because of the gold fever, as they were small towns and didn´t have many medical attention diseases spread more and were more fatal, the cholera plague took many lifes during the 18th centuries, causing people to leave the towns were people was getting infected and taking with them the infection to other towns, this led to many ghost towns where all the population had either died or left.