What effect did settlers have on native americans in the southearn colony?

The way this small state - large state compromise guards against tyranny is that small states and large states have one note: i am sorry but i was not able to give you the full answer. but i got this answer from

There’s no picture, but i’ll give you a few of expeditions. lewis and clark began in 1804, louisiana purchase 1802, james town 1607