How did american indians react to american settlers in the late 1700s and early 1800s? a. most american indians lived west of the appalachians, so settlement had little effect on them. b. settlement affected american indians very little, but they resented the arrival of explorers. c. the two groups were trading partners, so both sides lived in peaceful coexistence. d. american settlers and american indians often clashed as settlement spread across t