How did the political borders of the world change during the period of alexander’s rule?

At the time of his death, Alexander's empire covered some 5,200,000 km2 (2,000,000 sq mi),[203] and was the largest state of its time. Many of these areas remained in Macedonian hands or under Greek influence for the next 200–300 years. The successor states that emerged were, at least initially, dominant forces, and these 300 years are often referred to as the Hellenistic period.

geography

this is because warmer climates often don't get people sick from the flu and regions where it was often colder more people received the flu. hope this if you need more reasoning i am here to