As a result of not being able to interact with one another, what did the city-s tates develop over time?

if you're talking about the greek city-states, here ya go :)

Explanation:

greek city-states likely developed because of the physical geography of the mediterranean region. the landscape features rocky, mountainous land and many islands. these physical barriers caused population centers to be relatively isolated from each other. the sea was often the easiest way to move from place to place.

so, with that being said, i would assume water-crafts such as ships or smaller boats.

john locke studied medicine and he laid a lot of groundwork for the enlightenment he also contibutied to the development of liberalism