What are the shortcomings of science-based, Enlightenment thinking?

It was driven by scepticism about traditional ideas and beliefs, intellectual curiosity and a desire for social, political and technical progress. Enlightenment thinkers and writers challenged existing knowledge and assumptions, seeking new information and a better understanding of humanity and the natural world.

Explanation:

powers  are  denied  to the  national governmentin three distinct ways: some  powers, such as the  power  to levy duties on exports or prohibit the freedom of religion, speech, press, or assembly, are expressly  denied  to the  national government  in the  constitution.