HELP I AM BEING TIMED, also ill give brainliest Which was the greatest challenge for both American settlers and American Indians in the West in the mid-1800s?
A. the exposure to harsh weather
B. the threat of deadly diseases
C. the danger of crossing difficult terrain
D. the problem of fenced-off land

A) the exposure to harsh weather. Many pioneers and settlers at this time struggles with the disastrous weather conditions including extended winters and strong winds. The west part of the US differed tremendously (geography wise) than that of the East thus the instances of horrendous weather throughout the seasons both the pioneers and settles overcame alike.