"This spring, also, those Indians that lived about their trading house there fell sick of small pox, and died most miserably" What was the primary cause of this situation?

This spring also, these Indians that lived about their trading house there, fell sick of the small pox and died most miserably; for a sorer disease cannot befall them, they fear it more than the plague. ... And then being very sore, what with cold and other distempers, they die like rotten sheep.

Explanation:

d. migration of french settlers into english colonies

pepin the short[a] (german: pippin der kurze, french: pépin le bref, c. 714 – 24 september 768) was the king of the franks from 751 until his death. he was the first of the carolingians to become king.[b][2]

the younger son of the frankish prince charles martel and his wife rotrude, pepin's upbringing was distinguished by the ecclesiastical education he had received from the monks of st. denis. succeeding his father as the mayor of the palace in 741, pepin reigned over francia jointly with his elder brother carloman. pepin ruled in neustria, burgundy, and provence, while his brother carloman established himself in austrasia, alemannia and thuringia. the brothers were active in suppressing revolts led by the bavarians, aquitanians, saxons, and the alemanni in the early years of their reign. in 743, they ended the frankish interregnum by choosing childeric iii, who was to be the last merovingian monarch, as figurehead king of the franks.