John Locke and other Enlightenment thinkers emphasized
over religion.

This Question represents a fundamental misunderstanding of Locke's beliefs

Explanation: There are no answer choices provided, and I will thus assume that it is intended as an open ended question. While Locke did refute Robert Filmer's religious justification of a monarchy (Filmer argued modern rulers to be direct decendants of Adam), Locke's own philosophy did not stray very far from religious beliefs, and was instead rooted almost entirely in a different interpretation of scripture. Similar "Enlightenment" philosophers like Rousseau and Voltaire were also strong deists (Voltaire was also a monarchist), and based much of their philosophy

upon scripture. Indeed, some of the only Enlightenment philosophers who did not base their works almost entirely upon the scripture were Kant and Hume, although Hume's personal beliefs are unknown. The Enlightenment philosophers were not, as is often portrayed, an entirely homogenous group.

disease was the number one killer of native peoples. they had had little exposure to the diseases of europe. this led to some villages being almost completely wiped out and some tribes destroyed.