What effect did the introduction of smallpox have in the Americas? A.
It contributed to the defeat of American Indians.
B.
C.
It led to large numbers of deaths among European colonists in the Americas.
It allowed American Indians to quickly develop a resistance to the disease.
It resulted in the inability of Europeans to establish colonies in the Americas.
D.

A

Explanation:

The first epidemic that significantly affected the natives of the American continent was smallpox, brought in one of the ships of Christopher Columbus on his second visit to the New World. Native Americans were immediately infected as one of the populations susceptible to this disease, smallpox produced serious damage to the indigenous population, which had not been in contact with the disease.

the industrial development of cities in the ruhr area in the nineteenth century is described. the research was based on english and german language sources. several factors that shaped growth and paths of the cities were categorized and analyzed. they are locations, resources, traditions, entrepreneurs, and technological developments. locations and resources were the most important among them; other factors may be regarded as consequences from locations and resources. among the cities, bochum, essen, gelsenkirchen, and dortmund had the richest resources and most favorable locations in the transportation network and grew to be the largest cities in the ruhr area near the end of the nineteenth century. riverside location was also a favorable factor for the development, as shown in the development of duisburg on the confluence of rhine and ruhr. resource distribution can explain the rise of textile industry, metallurgical industry, and coal and iron industries, and the northward progression of the mining industry. tradition was an important factor for cities such as krefeld, barmen, elberfeld, solingen, and remscheid, which experienced development based on their traditions through the nineteenth century. various entrepreneurs exerted influences within and beyond the local level over the ruhr area. technological development stimulated the northward progression of the mining industry and the deep connection between the coal and the iron industries.