Because of the Great Lakes, Midwestern farmers have access to: all of the United States markets
markets on the the Atlantic coast
O markets all around the world
O markets on the Pacific coast

the doctrine of nullification recommended that states living inside the union have the one-sided, inalienable ideal to void any law made by the national government that could be esteemed illegal.

the united states was shaped based on a general agreement among its individual states. hence, it is inferred that under the hypothesis of invalidation, since the states are the establishment of the union, they have the ability to referee and disprove unlawful laws.

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explanation:

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the correct answer is "pioneers carried all of their possessions on long and dangerous trails".

the first wave of pioneers travelled in 1842. they were merely 100 people. the next year that sum climbed to 1000 men, women, and children. these people travelled around 2,000 miles to oregon in the hopes of a better life. although the first part of the trip didn't present many obstacles, as time and miles went by they learnt that threat came from simple things, like becoming ill due to unclean water or bad food.

the weather didn't much, as wagons couldn't protect them from storms. as they travelled through the desert, the intense heat caused wood to shrink. their own lips abscessed and split because of the dry air. the only cure for this was to rub axle grease on their lips.

even crossing rivers was dangerous. sometimes wheels were damaged by unseen rocks on shallow water. mud didn't much either. pioneers were afraid of indian attacks, but there aren't many records of fights between pioneers and native americans. accidents happened because of negligence, exhaustion, guns, and bad weather.

history says that 1 of 10 pioneers who travelled to oregon didn't survive the journey. diseases spread fastly because they didn't have doctors and medical care was ofently improvised. one of the most deadly diseases they came upon was cholera, which became a worldwide pandemia.