What was the major cause of conflict between england and spain in the 1500's

What does the quote describe? “the closeness of the place, and the heat of the climate, added to the number in the ship, which was so crowded that each had scarcely room to turn himself, almost suffocated us….the shrieks of the women, and the groans of the dying, rendered the whole a scene of horror almost inconceivable.”

Who was william johnson? a. a revolutionary war veteran b. was the most prominent free black in mississippi c. a field slave d. inventor of the cotton gin

What was the first major route to connect europe and asia