An effect of the diseases that were part of the columbian exchange was that:

Europeans took advantage of Native American societies weakened by disease

Explanation: Apex

these conditions long with a short growing season made farming difficult.

explanation:

the north has a climate of warm summers and snowy cold winters. the terrain is rocky, hilly, and not good for farming.

i confess that there are several parts of this constitution which i do not at present approve, but i am not sure i shall never approve them: for having lived long, i have experienced many instances of being obliged by better information or fuller consideration, to change opinions even on important subjects, which i once thought right, but found to be otherwise. it is therefore that the older i grow, the more apt i am to doubt my own judgment, and to pay more respect to the judgment of others.