What is the downside of a country turning towards isolation ?

Well, social isolation can lead to feelings of loneliness, fear of others, issues with reality, or negative self-esteem. Lack of consistent human contact can also cause conflict with the (peripheral) friends the socially isolated person may occasionally talk to someone/family.

the gutenberg bible was and about 180 copies were sold/made

the two things that develop a strong social foundation are: a. separation of church and states e. education received attention separation of church and states separate the illogical  argument that came from religious beliefs to a fact based belief. while education will make us remember the past to avoid the repeat of our mistakes.