In addition to several short-term effects of alcohol and drugs on the body, other negative physiological, physical, or logical effects can occur

Some long term effects can take place. 

Drugs and alcohol are extremely addictive, and can cause brain damage and several health issues. You are more likely to get cancer, and other deathly diseases by using them. 

You become emotionally and physically dependent on the drugs/ and or alcohol. You cannot function properly and may have serious mood swings for an extended period of time. It can also seriously increase your chance of developing mood, food, and other disorders. 

I hope this helped you, seeing as your statement wasn't really asking of anything. If you need more help, let me know.