8. Some patients with severe emphysema have constant high levels of Co, because of inadequate ventilation. The central nervous system breathing center in these patients
becomes insensitive to CO, and more dependent on the level of O2, which is low. These
patients are said to have "oxygen-dependent respiratory drive". What might happen if you
give such a person high levels of supplemental O2?

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for