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Diseases may arise when proteins fail to fold correctly in their last stages of processing and/or are directed towards the lysosome rather than towards the cell membrane. cystic fibrosis is an example of this type of disease. in cystic fibrosis, a functional ion channel is sent to the lysosome for destruction rather than being sent to the plasma membrane. given this observation, the cellular component that is most likely the cause of the disease is the

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Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for