According to the CDC, smoking can lead to Buerger's disease, which affects blood vessels in the arms and legs. Blood vessels swell, which can prevent blood flow, causing clots to form. This can lead to pain and tissue damage. Extreme cases can induce gangrene, which can require amputation. What statement best replaces the sentence, "Extreme cases can induce gangrene, which can necessitate amputation?"

Extreme cases can be caused by gangrene, which involves the removal of a limb.
Extreme cases can lead to gangrene, which can require removal of a limb.
Extreme cases can be caused by gangrene, which requires increased care.
Extreme cases can lead to gangrene, which involves involuntary care.

The statement "Extreme cases can induce gangrene, which can necessitate amputation" can be replaced by "Extreme cases can lead to gangrene, which can require removal of a limb."

Explanation:

The statement that is used in place of the original text makes it retain its meaning and communicating the same information in a more aesthetic way.

"Can induce" is replaced by "can lead", and "can require amputation" is changed to "can require removal of a limb", since in the first case the meaning is a "consequence of" and amputation means removal of a limb.

The other options are not used because:

explanation:

daily refers to frequency, like weekly or monthly. take this medicine twice daily, once in the morning and again at bedtime. on a daily basis there refers to everyday life, to one's normal or usual behavior, activity, routine, or schedule, to the quotidien.