Sick cell disease (SCD) primarily affects: A. children of African descent and Hispanics of Caribbean ancestry. B. children of Middle-Eastern and Indian descent. C. children of Asian descent. D. both African descent and Hispanics of Caribbean ancestry and Middle-Eastern and Indian descent.

Sick cell disease (SCD) primarily affects:both African descent and Hispanics of Caribbean ancestry and Middle-Eastern and Indian descent. Correct option is D.

Explanation:

Sickle cell disease is a sickle cell disorder in which the red cells become sickel- shaped when there are subjected to low oxygen tension. The clinical manifestations usually develops 3 to 4 months of age when the level of HbF ( foetal haemoglobin) falls and they include:

- impaired growth and development,

- splenomegaly,

- infection( due to impaired slpenic phagocytic function) and

- vaso- occlusive crises.

Sickle cell disease is divided into the following types:

- sickle cell anaemia

-Sickle cell B thalassemia.

The prevalence of SCD is worldwide with the different types occurring more in specific regions. Therefore option D is correct.

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