History: this 16yr old feamle is seen in the offic3 today by dr. Jacob's after falling off a curb and twisting her right ankle. She is normally a patient of dr. Anderson. Who is out of town this week. Sje states that she has pain surrounding the entire foot and ankle. Seems unable or unwilling to bear weight.

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for