Alice has felt ill for two weeks. She has had a runny nose every day and a fever of 100 degrees for two days. Her appetite has decreased slightly. She is tired and has not wanted to get out of bed.

Which symptom does Alice have that indicates that she should seek medical care?

A. tiredness
B. runny nose
C. fever over 99 degrees
D. illness for two weeks

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for