Iwill mark is the correct definition of a fracture? a bone coming out of its normal place in a joint break in the bone injury to the ligament connecting bones swelling of a tendon from overuse

A break in bone or cartilage

Explanation:

Although usually a result of trauma, a fracture can be the result of an acquired disease of bone, such as osteoporosis, or of abnormal formation of bone in a congenital disease of bone, such as osteogenesis imperfecta ('brittle bone disease').

pathogens is the answer