Which information flow is disrupted when diabetes destroys insulin-producing cells?

INSULIN producing cells are called beta cells in the Pancreas. The second cells are alpha cells which produce GLUCAGON ,

The function of Inslulin is to aid the entry of glucose through GLUT transporters 1 and 4 into the cells, by coordinating the breakdown of glycogen to glucose.(While glucagon ensures conversion stored glycogen to glucose )

When these beta cells are destroyed, cells are starved of glucose. since  glucose can not enter the cells as  INSULIN which regulate cascade event for the influx is  absent.

This leads to depletion of liver glycogen,  reduction in liver glycolysis,reduction in muscle glucose uptake, and liver glycogen fatty acid synthesis

Therefore Glucose accumulate in the blood stream ,  raising the solute potential of the blood  in relation to the plasma.

This lead to l massive excretion in the kidney  due to inability of the proximal tubule to reabsorbed  the excess glucose . A  lot is lost in urine leading to polyuria,(excess urination),  thirst from dehydration, and hyperphagia  ( high hunger , because body cells are starved of glucose}

The body compensate for this with gluconeogensis,by breaking down  Non carbohydrate molecules  triglycerides to Glucose,with ketone build up in the liver, inhibition of activities of Glucagon

Explanation: