During abstinence, the activity of the prefrontal cortex of people who abused cocaine was lower than that of non-cocaine-using participants.

Right lateral prefrontal cortex (LPFC)

Explanation:

Cocaine abusers showed less activity of right LPFC during abstinence period, which supports the hypothesis that heavy use of cocaine contributes to persistent prefrontal cortical dysfunction. One possible reason of low LPFC activity should be the vaso-constrictive action of cocaine which produce ischemic changes in the brain. Less oxygen delivery to the brain for longer periods of cocaine addiction results into permanent effects on right lateral prefrontal cortex.

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