How do leukocytes determine what should be in your body and what shouldn’t?

An increased number of WBCs seen in the urine under a microscope and/or positive test for leukocyte esterase may indicate an infection or inflammation somewhere in the urinary tract. If also seen with bacteria (see below), they indicate a likely urinary tract infectionTypes of WBCs. The different types of white blood cells (leukocytes) include neutrophils, basophils, eosinophils, lymphocytes, monocytes, and macrophages.White blood cells help all parts of the body fight infection. ... The following can also cause raised levels of leukocytes in the urine: some cancers, such as prostate, bladder, or kidney cancer.^-^

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perspiration and respiration.