What is the difference between a musculoskeletal disease and a musculoskeletal disorder? a disease has long-term consequences, and a disorder is a short-term illness for the individual. a disease causes severe, acute pain, and a disorder produces mild discomfort for the individual. a disease is an illness that is suddenly acquired, and a disorder is present at birth. a disease is an illness that has a recognizable set of symptoms, and a disorder is any abnormality of function.